Quantified Efficiency of Membrane Leakage Events Relates to Antimicrobial Selectivity

Physical basis for membrane-charge selectivity of cationic antimicrobial peptides.

Antimicrobial peptides are known to selectively disrupt (highly charged) microbial membranes by asymmetrical incorporation into the outer layers. We present a physical basis for membrane-charge selectivity of cationic antimicrobial peptides. In particular, we provide a clear picture of how peptide-charge Q influences the asymmetrical insertion--one salient feature is the existence of an optimal...

Membrane selectivity by W-tagging of antimicrobial peptides.

A pronounced membrane selectivity is demonstrated for short, hydrophilic, and highly charged antimicrobial peptides, end-tagged with aromatic amino acid stretches. The mechanisms underlying this were investigated by a method combination of fluorescence and CD spectroscopy, ellipsometry, and Langmuir balance measurements, as well as with functional assays on cell toxicity and antimicrobial effec...

Membrane reactors: A way to increase efficiency

Proto-dialytic cardiac function relates to intra-dialytic morbid events.

BACKGROUND Intra-dialytic morbid events (IDME) such as intra-dialytic hypotension (IDH) and muscle cramps frequently complicate haemodialysis (HD). Cardiac dysfunction is highly prevalent in HD patients. We investigated the relationship between proto-dialytic (i.e. early intra-dialytic) cardiac function and IDME in HD patients. METHODS Heart rate, beat-to-beat blood pressure (BP) and cardiac ...

A Preliminary Study of Quantified, Typed Events

In previous work, Rajan and Leavens presented the design of Ptolemy, a language which incorporates the notion of quantified, typed events for improved separation of concerns. In this work, we present an empirical study to evaluate the effectiveness of Ptolemy’s design by applying it to a series of architectural releases of a software product line (SPL) for handling multimedia on mobile devices,...